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* 66 pct cure amount apparent with Merck’s boceprevir

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* Merck to seek boceprevir approval by year’s end

* Ancillary furnishings accession questions in one of two trials

* Merck shares hardly higher

* Shares of battling drugmaker Vertex up 3.5 pct (Adds yst comments, capacity on Merck and Vertex drugs; changes byline)

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By Ransdell Pierson and Bill Berkrot

NEW YORK (Reuters) – Merck & Co said its beginning hepatitis C ysis met the capital capability goals of two late-stage studies and it expects to seek approval for the high-profile anesthetic by the end of the year.

But a abundant college allotment of patients demography the Merck drug, compared with those demography accepted treatments, abandoned out of one of the trials due to adverse events, including anemia.

The drug, boceprevir, was one of the best important beginning articles acquired by Merck through its accretion of Schering-Plough Corp aftermost year.

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In the two trials, 66 percent of patients who took boceprevir added accepted drugs for a abounding 48 weeks were convalescent of the austere alarmist disease, a decidedly college cure amount than for accepted ysis alone. But that compares with a 75 percent cure amount apparent in a abstracted balloon of a battling biologic actuality developed by Vertex Pharmaceuticals Inc.

Boceprevir and Vertex’s telaprevir are advised accessible blockbuster articles because of their abeyant to cure far added patients and in as little as bisected the time of accepted drugs that crave about a year of ysis and generally account flu-like affection that are boxy to tolerate.

Vertex shares rose 3.5 percent to $36.47 as investors compared the Merck abstracts with afresh appear abstracts on the Vertex drug. Merck said it would accommodate added abundant ytic balloon abstracts at a affair of the American Association for the Abstraction of Alarmist Diseases that begins Oct. 29 in Boston.

Merck shares rose 19 cents, or 0.5 percent, to $35.01.

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The new chic of drugs, which are accumulated with accepted treatments, assignment adjoin the liver-damaging hepatitis C virus by blocking a protein alleged protease that the virus requires to replicate. The accepted accepted treatments absorb a aggregate of the injectable biologic interferon and an anti-viral us alleged ribavirin.

“Based on today’s top band data, we are advancement our appearance that, while telaprevir will acceptable booty a majority of the antecedent hepatitis C protease inhibitor market, boceprevir will comedy a role in the category,” J.P. Morgan yst Chris Schott said in a ysis note.

Schott said investors will get a bigger account of the corresponding strengths and shortcomings of the two drugs back abounding late-stage balloon abstracts on telaprevir and boceprevir are apparent at the accessible Boston meeting.

Merck said boceprevir, taken in aggregate with the company’s Pegintron cast of interferon and ribavirin, decidedly added the cardinal of patients who accomplished a abiding virologic response, or SVR — acceptation no apparent virus levels 24 weeks afterwards the end of ysis — compared with those who accustomed the accepted drugs added a placebo.

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Achieving SVR, in layman’s terms, is advised actuality convalescent of the disease.

One of the trials, alleged HCV RESPOND-2, complex 403 patients with genotype 1, the best accepted anatomy of hepatitis C, who had bootless above-mentioned ysis with interferon and ribavirin. The added trial, alleged HCV SPRINT-2, enrolled 1,097 patients with genotype 1 who had not ahead been advised for the virus.

In both trials, a cogent cardinal of patients accustomed 48 abounding weeks of treatment. But patients with ephemeral virus at anniversary 8 and afresh at assertive credibility after in the studies were able to stop all ysis at 36 weeks in the abate trial, and at 28 weeks in the beyond study.

In the HCV RESPOND-2 study, 66 percent of those accepting boceprevir for 48 weeks were cured, while cures were apparent in 59 percent of those accepting beneath ysis regimens of the medicine. That compared with a 21 percent cure amount for those accepting accepted treatments.

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In the HCV SPRINT-2 abstraction of ahead basic patients, 66 percent of those accepting boceprevir for 48 weeks were cured, forth with 63 percent of those on beneath regimens. Cures were apparent in 38 percent of those accepting accepted therapy.

Telaprevir’s 75 percent cure amount in its own Phase III balloon activated the biologic in ahead basic patients.

Vertex is accepted aing ages to bare abstracts from addition late-stage balloon of telaprevir in tougher-to-treat patients who had bootless above-mentioned ysis with accepted drugs.

Sanford Bernstein yst Tim Anderson said accessible abstracts from abstracted trials of boceprevir and telaprevir advance the Merck biologic is beneath effective.

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Moreover, he said boceprevir seems added acceptable to account anemia — a ancillary aftereffect that could crave patients to booty intravenous anemia medicines that addition red claret cells. The catechism is whether the charge for an added anemia biologic on top of the three-drug dieting will abundantly abash use of boceprevir, should it be approved.

Anderson anticipation boceprevir would accumulate sales of $330 actor in 2015, far beneath his anticipation of $4.3 billion for the Vertex drug. (Reporting by Ransdell Pierson, Lewis Krauskopf and Bill Berkrot, alteration by Maureen Bavdek, Dave Zimmerman and John Wallace)

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